Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.60 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8420104 | 0.90 | PTGS2 (0.54) | SMN1; SMN2CHRNA7MAPK9PTGS2PTGS1 | |
| SCHEMBL8423935 | 0.82 | CHRNA7 (0.57) | SMN1; SMN2CHRNA7MAPK9PTGS2PTGS1 | |
| SCHEMBL28190691 | 0.80 | KMT2A (0.62) | PTGS1 | |
| SCHEMBL27436439 | 0.78 | PTGS2 (0.63) | SMN1; SMN2CHRNA7PTGS2PTGS1PDPK1 | |
| SCHEMBL8119257 | 0.78 | PTGS2 (0.67) | SMN1; SMN2CHRNA7MAPK9PTGS2PTGS1 | |
| SCHEMBL212707 | 0.78 | PTGS2 (0.80) | CHRNA7MAPK9PTGS2PTGS1PDPK1 | |
| SCHEMBL3873219 | 0.78 | CHRNA7 (0.80) | SMN1; SMN2CHRNA7MAPK9PTGS2 | |
| SCHEMBL8119702 | 0.78 | PTGS2 (0.74) | SMN1; SMN2CHRNA7PTGS2PTGS1 | |
| SCHEMBL8126719 | 0.78 | PTGS2 (0.74) | SMN1; SMN2CHRNA7PTGS2PTGS1 | |
| SCHEMBL7156590 | 0.78 | MALT1 (0.58) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908852-A | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation | G. D. SEARLE & CO. (US) | 1999-06-01 | — | — | US | disclosed |