Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.54 |
| ▸ | CA1 | P00915 | 3/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8423812 | 0.90 | PTGS2 (0.54) | CHRNA7PTGS2PTGS1SMN1; SMN2 | |
| SCHEMBL8420064 | 0.82 | SMN1; SMN2 (0.62) | CHRNA7PTGS2PTGS1CA1CA2 | |
| SCHEMBL8733986 | 0.79 | PTGS2 (0.60) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL212707 | 0.78 | PTGS2 (0.80) | CHRNA7PTGS2PTGS1MMP2CYP2C9 | |
| SCHEMBL8692916 | 0.78 | PTGS2 (0.60) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL8120201 | 0.78 | PTGS2 (0.66) | CHRNA7PTGS2PTGS1SMN1; SMN2MMP2 | |
| SCHEMBL8119702 | 0.78 | PTGS2 (0.74) | CHRNA7PTGS2PTGS1SMN1; SMN2CYP2C9 | |
| SCHEMBL8126719 | 0.78 | PTGS2 (0.74) | CHRNA7PTGS2PTGS1SMN1; SMN2CYP2C9 | |
| SCHEMBL8126788 | 0.77 | PTGS2 (0.74) | CHRNA7PTGS2PTGS1SMN1; SMN2CYP2C9 | |
| SCHEMBL8122672 | 0.77 | PTGS2 (0.74) | CHRNA7PTGS2PTGS1SMN1; SMN2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908852-A | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation | G. D. SEARLE & CO. (US) | 1999-06-01 | — | — | US | disclosed |