Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 7/20 | 0.45 |
| ▸ | NAALAD2 | Q9Y3Q0 | 4/20 | 0.45 |
| ▸ | FPR2 | P25090 | 1/20 | 0.44 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GRN | P28799 | 1/20 | 0.43 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8420087 | 1.00 | CA1 (0.46) | CA1CA2FOLH1NAALAD2FPR2 | |
| SCHEMBL7676506 | 0.90 | HPGD (0.43) | SMN1; SMN2GAA | |
| SCHEMBL8004412 | 0.90 | HPGD (0.43) | SMN1; SMN2GAA | |
| SCHEMBL7673756 | 0.90 | HPGD (0.43) | SMN1; SMN2GAA | |
| SCHEMBL1824097 | 0.85 | GRN (0.61) | CA1CA2FPR2SMN1; SMN2GRN | |
| SCHEMBL1824098 | 0.85 | GRN (0.61) | CA1CA2FPR2SMN1; SMN2GRN | |
| SCHEMBL1823125 | 0.82 | FPR2 (0.68) | CA1CA2FPR2 | |
| SCHEMBL1824158 | 0.82 | FPR2 (0.68) | CA1CA2FPR2 | |
| SCHEMBL1823124 | 0.82 | FPR2 (0.68) | CA1CA2FPR2 | |
| SCHEMBL7681041 | 0.80 | CASP3 (0.44) | SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942923-A2 | N-(ARYL/HETEROARYL) AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING $g(b)-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS | Elan Pharmaceuticals, Inc. (US) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998022493-A2 | N-(ARYL/HETEROARYL) AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS | ELAN PHARMACEUTICALS, INC. (US) | 1998-05-28 | — | — | WO | disclosed |