Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | LTB4R | Q15722 | 5/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 5/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8422487 | 0.87 | KDM4E (0.46) | PTGESALOX5PPARGAKR1C3 | |
| SCHEMBL8573087 | 0.86 | LTB4R (0.50) | PTGESALOX5PPARGLTB4RLTB4R2 | |
| SCHEMBL8418931 | 0.86 | LTB4R (0.50) | PTGESALOX5PPARGLTB4RLTB4R2 | |
| SCHEMBL8420123 | 0.86 | AKR1C3 (0.46) | PTGESALOX5PPARGLTB4RLTB4R2 | |
| SCHEMBL8560590 | 0.83 | TSHR (0.40) | PTGESALOX5PPARGAKR1C3 | |
| SCHEMBL8422459 | 0.81 | PPARG (0.46) | PTGESALOX5PPARGAKR1C3 | |
| SCHEMBL8422418 | 0.81 | S1PR1 (0.45) | PTGESALOX5PPARGLTB4RLTB4R2 | |
| SCHEMBL8418898 | 0.80 | LTB4R (0.65) | LTB4RLTB4R2 | |
| SCHEMBL8420129 | 0.78 | LTB4R (0.67) | LTB4RLTB4R2 | |
| SCHEMBL8420619 | 0.78 | LTB4R (0.67) | LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | claimed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | claimed |
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | disclosed |