Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 5/20 | 0.46 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.44 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | PTGES | O14684 | 3/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.42 |
| ▸ | PPARG | P37231 | 3/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8573087 | 0.92 | LTB4R (0.50) | AKR1C3LTB4RLTB4R2APPPTGES | |
| SCHEMBL8418931 | 0.92 | LTB4R (0.50) | AKR1C3LTB4RLTB4R2APPPTGES | |
| SCHEMBL8422487 | 0.87 | KDM4E (0.46) | AKR1C3APPPTGESALOX5PPARG | |
| SCHEMBL8420132 | 0.86 | PTGES (0.42) | AKR1C3LTB4RLTB4R2PTGESALOX5 | |
| SCHEMBL8422459 | 0.85 | PPARG (0.46) | AKR1C3APPPTGESALOX5PPARG | |
| SCHEMBL8560590 | 0.83 | TSHR (0.40) | AKR1C3APPPTGESALOX5PPARG | |
| SCHEMBL8565773 | 0.82 | LTB4R (0.53) | LTB4RLTB4R2APPLMNA | |
| SCHEMBL8418438 | 0.80 | LTB4R (0.54) | LTB4RLTB4R2S1PR1LMNA | |
| SCHEMBL8420120 | 0.78 | LTB4R (0.71) | LTB4RLTB4R2 | |
| SCHEMBL8422495 | 0.75 | LTB4R (0.52) | AKR1C3LTB4RLTB4R2APPPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | disclosed |