Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 9/20 | 0.65 |
| ▸ | LTB4R2 | Q9NPC1 | 9/20 | 0.65 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8422218 | 0.88 | LTB4R (0.50) | LTB4RLTB4R2PTGER1MEN1LMNA | |
| SCHEMBL8418885 | 0.86 | LTB4R (0.65) | LTB4RLTB4R2MEN1KMT2AAPP | |
| SCHEMBL8565773 | 0.85 | LTB4R (0.53) | LTB4RLTB4R2PTGER1MEN1LMNA | |
| SCHEMBL4961192 | 0.84 | LTB4R (0.49) | LTB4RLTB4R2PTGER1MEN1LMNA | |
| SCHEMBL8418922 | 0.81 | LTB4R (0.57) | LTB4RLTB4R2PTGER1MEN1KMT2A | |
| SCHEMBL8420132 | 0.80 | PTGES (0.42) | LTB4RLTB4R2 | |
| SCHEMBL7987218 | 0.78 | LTB4R (1.00) | LTB4RLTB4R2 | |
| SCHEMBL7987214 | 0.78 | LTB4R (1.00) | LTB4RLTB4R2 | |
| SCHEMBL7987221 | 0.78 | LTB4R (1.00) | LTB4RLTB4R2 | |
| SCHEMBL8420359 | 0.78 | LTB4R (0.52) | LTB4RLTB4R2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | disclosed |