Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8421979 | 1.00 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2NPC1RAB9ATAAR1 | |
| SCHEMBL8420779 | 0.94 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2PTGS2MAPTPTGS1 | |
| SCHEMBL8421776 | 0.91 | KDM1A (0.47) | SMN1; SMN2NPC1RAB9AKDM1APTGS2 | |
| SCHEMBL8420831 | 0.91 | GAA (0.43) | ALDH1A1SMN1; SMN2NPC1RAB9ATAAR1 | |
| SCHEMBL8420791 | 0.91 | GAA (0.43) | ALDH1A1SMN1; SMN2NPC1RAB9ATAAR1 | |
| SCHEMBL8641119 | 0.90 | AURKA (0.46) | SMN1; SMN2NPC1RAB9AKDM1APTGS2 | |
| SCHEMBL8026973 | 0.88 | CYP2C9 (0.47) | SMN1; SMN2KDM1APTGS2AURKAMALT1 | |
| SCHEMBL8422295 | 0.88 | CYP2C9 (0.47) | SMN1; SMN2KDM1APTGS2AURKAMALT1 | |
| SCHEMBL8421856 | 0.86 | KDM1A (0.41) | ALDH1A1SMN1; SMN2KDM1APTGS2AURKA | |
| SCHEMBL8424007 | 0.85 | MAPT (0.46) | ALDH1A1SMN1; SMN2NPC1RAB9AKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908852-A | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation | G. D. SEARLE & CO. (US) | 1999-06-01 | — | — | US | disclosed |