Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 4/20 | 0.50 |
| ▸ | NOS1 | P29475 | 4/20 | 0.50 |
| ▸ | NOS2 | P35228 | 4/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974091 | 0.92 | NOS3 (0.57) | NOS3NOS1NOS2TAS1R3TAS1R1 | |
| SCHEMBL7676887 | 0.92 | NOS3 (0.57) | NOS3NOS1NOS2TAS1R3TAS1R1 | |
| SCHEMBL7679816 | 0.92 | TAS1R3 (0.49) | NOS3NOS1NOS2TAS1R3TAS1R1 | |
| SCHEMBL7674505 | 0.92 | NOS3 (0.57) | NOS3NOS1NOS2TAS1R3TAS1R1 | |
| SCHEMBL7674513 | 0.92 | NOS3 (0.57) | NOS3NOS1NOS2TAS1R3TAS1R1 | |
| SCHEMBL7679822 | 0.92 | TAS1R3 (0.49) | NOS3NOS1NOS2TAS1R3TAS1R1 | |
| SCHEMBL7975055 | 0.92 | TAS1R3 (0.49) | NOS3NOS1NOS2TAS1R3TAS1R1 | |
| SCHEMBL8423095 | 0.88 | TAS1R3 (0.49) | NOS3NOS1NOS2TAS1R3TAS1R1 | |
| SCHEMBL8418928 | 0.87 | NOS2 (0.50) | NOS3NOS1NOS2ALDH1A1HTT | |
| SCHEMBL8418925 | 0.87 | NOS2 (0.50) | NOS3NOS1NOS2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942923-A2 | N-(ARYL/HETEROARYL) AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING $g(b)-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS | Elan Pharmaceuticals, Inc. (US) | 1999-09-22 | — | — | EP | claimed |
| WO-1998022493-A2 | N-(ARYL/HETEROARYL) AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS | ELAN PHARMACEUTICALS, INC. (US) | 1998-05-28 | — | — | WO | claimed |