Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8420079 | 0.91 | PTGS2 (0.66) | PTGS2CYP2C9PTGS1 | |
| SCHEMBL8423065 | 0.91 | PTGS2 (0.66) | PTGS2CYP2C9PTGS1ALOX5PPP1CA | |
| SCHEMBL8125767 | 0.90 | PTGS2 (0.68) | PTGS2CYP2C9PTGS1ALOX5SMN1; SMN2 | |
| SCHEMBL8420757 | 0.88 | PTGS2 (0.67) | PTGS2CYP2C9PTGS1ALOX5 | |
| SCHEMBL8420798 | 0.88 | PTGS2 (0.80) | PTGS2CYP2C9PTGS1ALOX5PPP1CA | |
| SCHEMBL8424052 | 0.88 | PTGS2 (0.80) | PTGS2CYP2C9PTGS1ALOX5PPP1CA | |
| SCHEMBL8423624 | 0.87 | PTGS2 (0.69) | PTGS2CYP2C9PTGS1ALOX5CHRNA7 | |
| SCHEMBL8422369 | 0.85 | PTGS2 (0.70) | PTGS2CYP2C9PTGS1ALOX5CHRNA7 | |
| SCHEMBL8420804 | 0.85 | PTGS2 (0.88) | PTGS2CYP2C9PTGS1ALOX5 | |
| SCHEMBL8420088 | 0.85 | PTGS2 (0.66) | PTGS2CYP2C9PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908852-A | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation | G. D. SEARLE & CO. (US) | 1999-06-01 | — | — | US | disclosed |
| US-5434178-A | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation | G.D. SEARLE & CO. (US) | 1995-07-18 | — | — | US | disclosed |