Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.70 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8421613 | 0.91 | PTGS2 (0.70) | PTGS2PTGS1ALOX5CHRNA7MALT1 | |
| SCHEMBL8424001 | 0.91 | PTGS2 (0.70) | PTGS2PTGS1CHRNA7 | |
| SCHEMBL8423791 | 0.90 | PTGS2 (0.69) | PTGS2PTGS1ALOX5CHRNA7CYP2C9 | |
| SCHEMBL8111892 | 0.88 | PTGS2 (0.70) | PTGS2PTGS1CHRNA7CYP2C9 | |
| SCHEMBL8420804 | 0.88 | PTGS2 (0.88) | PTGS2PTGS1ALOX5MALT1CYP2C9 | |
| SCHEMBL8420754 | 0.85 | PTGS2 (0.66) | PTGS2PTGS1ALOX5CHRNA7CYP2C9 | |
| SCHEMBL8422267 | 0.85 | PTGS2 (0.75) | PTGS2PTGS1ALOX5CHRNA7MALT1 | |
| SCHEMBL8422328 | 0.84 | PTGS2 (0.65) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL8420090 | 0.84 | PTGS2 (0.78) | PTGS2PTGS1ALOX5CHRNA7MALT1 | |
| SCHEMBL8423720 | 0.84 | PTGS2 (0.74) | PTGS2PTGS1CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908852-A | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation | G. D. SEARLE & CO. (US) | 1999-06-01 | — | — | US | disclosed |
| US-5434178-A | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation | G.D. SEARLE & CO. (US) | 1995-07-18 | — | — | US | disclosed |