Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 6/20 | 0.34 |
| ▸ | RAB9A | P51151 | 6/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17039078 | 0.85 | GAA (0.38) | GAAL3MBTL1KMT2AMEN1NPC1 | |
| SCHEMBL22553973 | 0.81 | RAB9A (0.35) | KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL29822372 | 0.74 | GAA (0.40) | MAPTGAAL3MBTL1KMT2AMEN1 | |
| SCHEMBL14899361 | 0.74 | CHRNB2 (0.44) | MAPTKMT2ANPC1RAB9A | |
| SCHEMBL8422039 | 0.73 | FKBP1A (0.45) | — | |
| SCHEMBL8369393 | 0.73 | CHRNB2 (0.44) | MAPTL3MBTL1KMT2AMEN1NPC1 | |
| SCHEMBL30731271 | 0.72 | RAB9A (0.32) | KMT2ANPC1RAB9A | |
| SCHEMBL2653632 | 0.72 | KMT2A (0.40) | GAAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL25010722 | 0.71 | CHRNB2 (0.39) | KMT2ANPC1RAB9ACHRM1 | |
| SCHEMBL17037033 | 0.71 | CHRNB2 (0.39) | KMT2ANPC1RAB9ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0947506-A1 | 2-Aza-bicyclo[2.2.1]heptane derivatives and their use as rotamase inhibitors | Pfizer Products Inc. (US) | 1999-10-06 | — | — | EP | disclosed |