Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.31 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.31 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.31 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.31 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | FABP3 | P05413 | 1/20 | 0.31 |
| ▸ | FABP4 | P15090 | 1/20 | 0.31 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8420002 | 0.92 | MAP4K1 (0.36) | MAPTKDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL8421176 | 0.92 | CFTR (0.38) | DHODHMAPTKDM4EALDH1A1MCL1 | |
| SCHEMBL8417199 | 0.84 | ALDH1A1 (0.39) | MAPTKDM4EALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL8635491 | 0.84 | DHODH (0.35) | DHODHAGTR1AGTR2CYP3A4CYP2C9 | |
| SCHEMBL8419217 | 0.83 | AGTR1 (0.33) | DHODHAGTR1ALDH1A1MEN1TSHR | |
| SCHEMBL8419087 | 0.83 | DHODH (0.32) | DHODHAGTR1AGTR2 | |
| SCHEMBL8421698 | 0.81 | AGTR1 (0.41) | AGTR1AGTR2CYP3A4CYP2C9 | |
| SCHEMBL8417941 | 0.81 | PPARG (0.35) | AGTR1AGTR2CYP3A4CYP2C9 | |
| SCHEMBL8418024 | 0.81 | ALDH1A1 (0.36) | AGTR1AGTR2ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL8519654 | 0.80 | AGTR1 (0.33) | AGTR1AGTR2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962491-A | ANGIOTENSIN ANTAGONIST, HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, STROKES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-05 | — | — | US | disclosed |
| US-5705517-A | ANGIOTENSIN II ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-01-06 | — | — | US | disclosed |
| US-5703110-A | HYPOTENSIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-12-30 | — | — | US | disclosed |