Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 4/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | CDC25A | P30304 | 1/20 | 0.37 |
| ▸ | CDC25B | P30305 | 1/20 | 0.37 |
| ▸ | NAT1 | P18440 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8421920 | 0.84 | PTGES (0.44) | PTGESALOX5MALT1NPSR1KDM1A | |
| SCHEMBL8689212 | 0.82 | PTGS1 (0.51) | PTGESALOX5MALT1NPSR1KDM1A | |
| SCHEMBL8423988 | 0.82 | PTGES (0.43) | PTGESALOX5MALT1NPSR1KDM1A | |
| SCHEMBL8424009 | 0.82 | PTGES (0.43) | PTGESALOX5MALT1NPSR1KDM1A | |
| SCHEMBL8424177 | 0.82 | PTGES (0.43) | PTGESALOX5MALT1NPSR1KDM1A | |
| SCHEMBL8423891 | 0.82 | ALDH1A1 (0.43) | PTGESALOX5MALT1NPSR1KDM1A | |
| SCHEMBL8422206 | 0.81 | PTGES (0.42) | PTGESALOX5MALT1NPSR1KDM1A | |
| SCHEMBL8421700 | 0.79 | PTGES (0.43) | PTGESALOX5MALT1NPSR1KDM1A | |
| SCHEMBL8422345 | 0.79 | PTGES (0.41) | PTGESALOX5MALT1NPSR1KDM1A | |
| SCHEMBL8421861 | 0.79 | PTGES (0.41) | PTGESALOX5MALT1NPSR1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908852-A | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation | G. D. SEARLE & CO. (US) | 1999-06-01 | — | — | US | disclosed |