Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.69 |
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | HTT | P42858 | 4/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | APP | P05067 | 1/20 | 0.69 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.65 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.65 |
| ▸ | ABL1 | P00519 | 1/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.65 |
| ▸ | PIM1 | P11309 | 1/20 | 0.65 |
| ▸ | PRKACA | P17612 | 1/20 | 0.65 |
| ▸ | LTK | P29376 | 1/20 | 0.65 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.65 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.65 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.65 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.65 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.65 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.65 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8497590 | 0.82 | APP (1.00) | EGFRLMNAHTTMAPK1APP | |
| SCHEMBL1520577 | 0.81 | LMNA (0.75) | EGFRLMNAHTTMAPK1APP | |
| SCHEMBL12199178 | 0.81 | SMN1; SMN2 (0.77) | EGFRLMNAHTTMAPK1APP | |
| SCHEMBL29898477 | 0.81 | LMNA (0.75) | EGFRLMNAHTTMAPK1APP | |
| SCHEMBL29898476 | 0.81 | LMNA (0.75) | EGFRLMNAHTTMAPK1APP | |
| SCHEMBL13283188 | 0.80 | L3MBTL1 (0.65) | EGFRLMNAHTTMAPK1APP | |
| SCHEMBL11260593 | 0.80 | PIK3CD (0.71) | EGFRLMNAHTTMAPK1APP | |
| SCHEMBL8920 | 0.79 | EGFR (1.00) | EGFRHTTMAPK1ABCG2DAPK3 | |
| SCHEMBL29941271 | 0.79 | EGFR (1.00) | EGFRHTTMAPK1ABCG2DAPK3 | |
| SCHEMBL8483442 | 0.78 | HTT (0.67) | EGFRLMNAHTTMAPK1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946549-A1 | COMBINATORIAL PROCESS FOR PREPARING FUSED PYRIMIDINE LIBRARIES | ELI LILLY AND COMPANY (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998027087-A1 | COMBINATORIAL PROCESS FOR PREPARING FUSED PYRIMIDINE LIBRARIES | ELI LILLY AND COMPANY (US) | 1998-06-25 | — | — | WO | disclosed |