Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 17/20 | 0.73 |
| ▸ | NR3C1 | P04150 | 15/20 | 0.63 |
| ▸ | AR | P10275 | 12/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9019789 | 0.89 | PGR (0.69) | PGRNR3C1ARCYP3A4CYP2C8 | |
| SCHEMBL8423175 | 0.84 | PGR (1.00) | PGRNR3C1ARCYP3A4CYP2C8 | |
| SCHEMBL9019814 | 0.83 | PGR (0.71) | PGRNR3C1ARCYP3A4NR3C2 | |
| SCHEMBL9019846 | 0.79 | NR3C1 (0.83) | PGRNR3C1ARCYP3A4CYP2C8 | |
| SCHEMBL9019768 | 0.79 | PGR (0.68) | PGRNR3C1ARCYP3A4CYP2C8 | |
| SCHEMBL9019878 | 0.79 | NR3C1 (0.69) | PGRNR3C1ARCYP3A4CYP2C8 | |
| SCHEMBL30107690 | 0.78 | PGR (0.66) | PGRNR3C1ARCYP3A4CYP2C8 | |
| SCHEMBL20048408 | 0.78 | NR3C1 (0.81) | PGRNR3C1ARCYP3A4CYP2C8 | |
| SCHEMBL6453812 | 0.77 | PGR (0.65) | PGRNR3C1ARCYP3A4CYP2C8 | |
| SCHEMBL7148546 | 0.77 | PGR (0.65) | PGRNR3C1ARCYP3A4CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0404283-B1 | 11-Beta-aryl-4-estrene, method for its production and its use as a medicine | SCHERING AG (DE) | 1996-05-08 | — | — | EP | claimed |
| EP-0404283-B1 | 11-Beta-aryl-4-estrene, method for its production and its use as a medicine | SCHERING AG (DE) | 1996-05-08 | — | — | EP | disclosed |