Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA3 | P07451 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16047247 | 0.87 | KMT2A (0.52) | KMT2AGSK3BPTPN1CA12CA1 | |
| SCHEMBL8424913 | 0.85 | HDAC3 (0.51) | KMT2AGSK3BPTPN1CA12CA1 | |
| SCHEMBL7909243 | 0.83 | KMT2A (0.49) | KMT2AGSK3BPTPN1CA12CA1 | |
| SCHEMBL31131464 | 0.83 | KMT2A (0.49) | KMT2AGSK3BPTPN1CA12CA1 | |
| SCHEMBL10952894 | 0.81 | GSK3B (0.50) | KMT2AGSK3BPTPN1CA12CA1 | |
| SCHEMBL6830395 | 0.81 | KMT2A (0.47) | KMT2AGSK3BPTPN1CA12CA1 | |
| SCHEMBL6549496 | 0.79 | IDO1 (0.53) | KMT2AGSK3BPTPN1GPR139CES1 | |
| SCHEMBL22616327 | 0.79 | KMT2A (0.46) | KMT2AGSK3BPTPN1CA12CA1 | |
| SCHEMBL6057351 | 0.79 | KMT2A (0.50) | KMT2AGSK3BPTPN1GPR139CES1 | |
| SCHEMBL6057430 | 0.79 | ALDH1A1 (0.48) | KMT2AGSK3BPTPN1GPR139CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728591-B1 | GAPMER OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE | ROCHE INNOVATION CT COPENHAGEN AS (DK) | 2025-07-23 | — | — | EP | disclosed |
| EP-3728590-B1 | NOVEL THIOPHOSPHORAMIDITES | ROCHE INNOVATION CT COPENHAGEN AS (DK) | 2025-07-02 | — | — | EP | disclosed |
| CN-111448316-B | Novel thiophosphorous acid amides | 罗氏创新中心哥本哈根有限公司 | 2025-02-14 | — | — | CN | disclosed |
| US-20240368593-A1 | GAPMER OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE | ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) | 2024-11-07 | — | — | US | disclosed |
| EP-3728592-B1 | OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE | ROCHE INNOVATION CT COPENHAGEN AS (DK) | 2024-05-29 | — | — | EP | disclosed |
| US-11597926-B2 | Thiophosphoramidites | ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) | 2023-03-07 | — | — | US | disclosed |
| US-11597926-B2 | Thiophosphoramidites | ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) | 2023-03-07 | — | — | US | disclosed |
| US-20230002762-A1 | OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE | ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) | 2023-01-05 | — | — | US | disclosed |
| US-20230002762-A1 | OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE | ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) | 2023-01-05 | — | — | US | disclosed |
| EP-4092117-A1 | GAPMER OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE | Roche Innovation Center Copenhagen A/S (DK) | 2022-11-23 | — | — | EP | disclosed |
| US-20200339982-A1 | OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE | ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) | 2020-10-29 | — | — | US | disclosed |
| EP-3728590-A1 | NOVEL THIOPHOSPHORAMIDITES | Roche Innovation Center Copenhagen A/S (DK) | 2020-10-28 | — | — | EP | disclosed |
| EP-3728592-A1 | OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE | Roche Innovation Center Copenhagen A/S (DK) | 2020-10-28 | — | — | EP | disclosed |
| EP-3728591-A1 | GAPMER OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE | Roche Innovation Center Copenhagen A/S (DK) | 2020-10-28 | — | — | EP | disclosed |
| US-20200332289-A1 | GAPMER OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE | ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) | 2020-10-22 | — | — | US | disclosed |
| US-20200332289-A1 | GAPMER OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE | ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) | 2020-10-22 | — | — | US | disclosed |
| CN-111448316-A | Novel thiophosphorous acid amides | 罗氏创新中心哥本哈根有限公司 | 2020-07-24 | — | — | CN | disclosed |
| EP-0757060-B1 | Process for producing vinyl alcohol polymer | KURARAY CO (JP) | 1999-10-20 | — | — | EP | disclosed |
| US-5710211-A | REACTION OF POLYMER WITH COMPOUND HAVING A THIOL OR THIOESTER AND HYDROLYSIS TO FORM VINYL ALCOHOL | KURARAY CO., LTD. (JP) | 1998-01-20 | — | — | US | disclosed |
| EP-0757060-A2 | Process for producing vinyl alcohol polymer | KURARAY CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230002762-A1 | OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE | DUT, TYMP, TYMS | KMT2A 2877/4885GSK3B 3837/4885PTPN1 2570/4885 |
| US-20200339982-A1 | OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE | DUT, TYMP, TYMS | KMT2A 2807/4885GSK3B 3948/4885PTPN1 2430/4885 |
| US-11597926-B2 | Thiophosphoramidites | TYMP, RRM2B, RRM2 | KMT2A 1594/4885GSK3B 2117/4885PTPN1 454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.