Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 4/20 | 0.64 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.64 |
| ▸ | PDK3 | Q15120 | 4/20 | 0.64 |
| ▸ | PDK4 | Q16654 | 4/20 | 0.64 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.51 |
| ▸ | PGR | P06401 | 5/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8423647 | 1.00 | PDK1 (0.64) | PDK1PDK2PDK3PDK4NR1I2 | |
| SCHEMBL8423021 | 0.84 | PGR (0.62) | PGRNR3C1SLC6A4ADORA3SLC6A2 | |
| SCHEMBL9541216 | 0.82 | PDK1 (0.74) | PDK1PDK2PDK3PDK4NR1I2 | |
| SCHEMBL8424854 | 0.80 | PGR (0.42) | PDK1PDK2PDK3PDK4PGR | |
| SCHEMBL8426916 | 0.80 | PGR (0.42) | PDK1PDK2PDK3PDK4PGR | |
| SCHEMBL8423587 | 0.78 | PGR (0.60) | PGRNR3C1SLC6A4ADORA3SLC6A2 | |
| SCHEMBL5172677 | 0.78 | PDK1 (1.00) | PDK1PDK2PDK3PDK4NR1I2 | |
| SCHEMBL29653691 | 0.78 | PDK1 (1.00) | PDK1PDK2PDK3PDK4NR1I2 | |
| SCHEMBL13013574 | 0.78 | AR (0.74) | PDK1PDK2PDK3PDK4NR1I2 | |
| SCHEMBL8424688 | 0.75 | PGR (0.62) | PGRNR3C1SLC6A4ADORA3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0582338-B1 | 17-Spiromethylene steroids | AKZO NOBEL NV (NL) | 1999-10-20 | — | — | EP | disclosed |
| US-5854235-A | 17-spiromethylene steroids | AKZO NOBEL N.V. (NL) | 1998-12-29 | — | — | US | disclosed |
| US-5712264-A | 17-spiromethylene steroids | AKZO NOBEL N.V. (NL) | 1998-01-27 | — | — | US | disclosed |
| EP-0582338-A2 | 17-Spiromethylene steroids | Akzo Nobel N.V. (NL) | 1994-02-09 | — | — | EP | disclosed |