SCHEMBL842390

SCHEMBL842390

NS(=O)(=O)c1ccc2nc3c(nc2c1)-c1cc(S(=O)(=O)O)cc2cc(S(=O)(=O)O)cc-3c12

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.54
NT5E P21589 2/20 0.41
LMNA P02545 1/20 0.38
PKM P14618 4/20 0.38
POLB P06746 1/20 0.38
GAA P10253 2/20 0.37
MAPT P10636 2/20 0.37
KDM4E B2RXH2 1/20 0.37
MEN1 O00255 1/20 0.37
RAB9A P51151 1/20 0.37
KMT2A Q03164 1/20 0.37
ALDH1A1 P00352 4/20 0.37
HSD17B10 Q99714 3/20 0.37
CASP6 P55212 2/20 0.37
CYP2C9 P11712 2/20 0.37
CYP2C19 P33261 2/20 0.37
CA1 P00915 6/20 0.36
NSD2 O96028 1/20 0.35
DUSP3 P51452 1/20 0.35
PTPN5 P54829 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL838123 0.96 TDP1 (0.49) TDP1NT5ELMNAPKMPOLB
SCHEMBL840742 0.94 TDP1 (0.50) TDP1NT5ELMNAPKMPOLB
SCHEMBL840932 0.91 TDP1 (0.51) TDP1NT5ELMNAPKMPOLB
SCHEMBL13772379 0.87 TDP1 (0.44) TDP1NT5ELMNAMAPTMEN1
SCHEMBL14845574 0.86 TDP1 (0.48) TDP1NT5ELMNAPKMPOLB
SCHEMBL13366657 0.85 TDP1 (0.42) TDP1NT5EPKMMEN1RAB9A
SCHEMBL14336345 0.85 RAB9A (0.50) TDP1NT5ELMNAPKMPOLB
SCHEMBL842682 0.84 TDP1 (0.41) TDP1NT5EPKMALDH1A1HSD17B10
SCHEMBL842805 0.83 NT5E (0.37) TDP1NT5EPKMMEN1RAB9A
SCHEMBL1450083 0.82 RAB9A (0.44) TDP1NT5EPKMPOLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8416376-B2 Compensated in-plane switching mode liquid crystal display CRYSOPTIX KK (JP) 2013-04-09 US disclosed
US-8142863-B2 Color liquid crystal display and compensation panel Crysoptix, KK (JP) 2012-03-27 US disclosed
US-7889297-B2 Liquid crystal display operating in a vertically aligned mode Crysoptix, KK (JP) 2011-02-15 US disclosed
US-20100149471-A1 Compensated In-Plane Switching Mode Liquid Crystal Display CRYSOPTIX KK (JP) 2010-06-17 US disclosed
US-20100118241-A1 Liquid Crystal Display Operating in a Vertically Aligned Mode CRYSOPTIX KK (JP) 2010-05-13 US disclosed
US-20090268136-A1 Color Liquid Crystal Display and Compensation Panel CRYSOPTIX KK (JP) 2009-10-29 US disclosed
US-20090191394-A1 Oarganic Compound, Optical Crystal Film and Method of Production Thereof CRYSOPTIX K.K. (JP) 2009-07-30 US disclosed
US-20090161037-A1 Backlight Module and Liquid Crystal Display Incorporating the Same CRYSOPTIX KK (JP) 2009-06-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090191394-A1 Oarganic Compound, Optical Crystal Film and Method of Production Thereof HCN3, CFH, KCNH1 TDP1 4786/4885NT5E 976/4885LMNA 895/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.