Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.60 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8692916 | 0.83 | PTGS2 (0.60) | PTGS2PTGS1ALDH1A1CA1CA2 | |
| SCHEMBL8423935 | 0.79 | CHRNA7 (0.57) | PTGS2PTGS1CA1CA2CA4 | |
| SCHEMBL5429991 | 0.79 | PTGS2 (0.60) | PTGS2PTGS1PDPK1CA1CA2 | |
| SCHEMBL5698629 | 0.79 | PDPK1 (0.62) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8638165 | 0.78 | PTGS2 (0.60) | PTGS2PTGS1PDPK1CA1CA2 | |
| SCHEMBL8632975 | 0.77 | CA1 (0.56) | PTGS2PTGS1KDM4EALDH1A1CA1 | |
| SCHEMBL5422320 | 0.77 | PTGS2 (0.67) | PTGS2PTGS1PDPK1CA1CA2 | |
| SCHEMBL3109092 | 0.76 | PTGS2 (0.60) | PTGS2PTGS1PDPK1CA1CA2 | |
| SCHEMBL27716957 | 0.76 | ALDH1A1 (0.50) | KDM4EALDH1A1 | |
| SCHEMBL3107359 | 0.75 | PTGS2 (0.69) | PTGS2PTGS1PDPK1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100379727-C | Substituted pyrazolyl benzenesulfonamides for the treatment of inflamation | SEARLE & CO (US) | 2008-04-09 | — | — | CN | disclosed |
| CN-1268614-C | Substituted pyrazolyl benzenesulfonamides for treating inflammation | SEARLE & CO (US) | 2006-08-09 | — | — | CN | disclosed |
| CN-1699347-A | Substituted pyrazolyl benzenesulfonamides for the treatment of inflamation | SEARLE & CO (US) | 2005-11-23 | — | — | CN | disclosed |
| CN-1495170-A | Substituted pyrazolyl benzenesulfonamides for treating inflammation | G.D.ɪ����˾ | 2004-05-12 | — | — | CN | disclosed |
| CN-1134418-C | Substituted pyrazolyl benzenesulfonamides for treating inflammation | - | 2004-01-14 | — | — | CN | disclosed |
| CN-1127484-C | Substituted pyrazolyl benzene sulfone amides compounds for curing inflammation | SEARLE & CO (US) | 2003-11-12 | — | — | CN | disclosed |
| CN-1280126-A | Substituted pyrazolyl benzenesulfonamides for treating inflammation | SEARLE & CO (US) | 2001-01-17 | — | — | CN | disclosed |
| CN-1280125-A | Substituted pyrazolyl benzene sulfone amides compounds for curing inflammation | SEARLE & CO (US) | 2001-01-17 | — | — | CN | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| CN-1141630-A | Substituted pyrazolyl benzenesulfonamides for treating inflammation | SEARLE & CO (US) | 1997-01-29 | — | — | CN | disclosed |