Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.60 |
| ▸ | MAPT | P10636 | 7/20 | 0.60 |
| ▸ | MEN1 | O00255 | 6/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | GAA | P10253 | 4/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | APP | P05067 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 4/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8020214 | 0.89 | KMT2A (0.66) | KMT2AMAPTMEN1ALDH1A1TDP1 | |
| SCHEMBL8424148 | 0.85 | APP (0.58) | KMT2AMAPTMEN1ALDH1A1TDP1 | |
| SCHEMBL6945778 | 0.84 | MAPT (0.56) | KMT2AMAPTMEN1ALDH1A1TDP1 | |
| SCHEMBL6951892 | 0.83 | KMT2A (0.62) | KMT2AMAPTMEN1ALDH1A1TDP1 | |
| SCHEMBL13122202 | 0.83 | NPC1 (0.59) | KMT2AMAPTMEN1ALDH1A1TDP1 | |
| SCHEMBL8428074 | 0.83 | GAA (0.59) | KMT2AMAPTMEN1ALDH1A1TDP1 | |
| SCHEMBL8427633 | 0.82 | ALDH1A1 (0.54) | KMT2AMAPTMEN1ALDH1A1TDP1 | |
| SCHEMBL19659980 | 0.81 | KMT2A (0.64) | KMT2AMAPTMEN1ALDH1A1TDP1 | |
| SCHEMBL4661859 | 0.81 | MAPT (0.68) | KMT2AMAPTMEN1ALDH1A1TDP1 | |
| SCHEMBL2203669 | 0.80 | MAPT (0.77) | KMT2AMAPTMEN1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1066138-C | 4-(arylaminomethylene)-2,4-dihydro-3-pyrazolones | MERCK PATENT GMBH (DE) | 2001-05-23 | — | — | CN | disclosed |
| US-5869516-A | 4-(arylaminomethylene)-2,4-dihydro-3-pyrazolones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-02-09 | — | — | US | disclosed |
| CN-1141291-A | 4-(Arylaminomethylene)-2,4-dihydro-3-pyrazolones | MERCK PATENT GMBH (DE) | 1997-01-29 | — | — | CN | disclosed |