SCHEMBL8424178

SCHEMBL8424178

Cc1c(-c2ccc(Cl)cc2)nn(-c2ccccc2S(N)(=O)=O)c1-c1ccc(Cl)cc1

nearest known ligand 0.47

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 7/20 0.47
PTGS1 P23219 1/20 0.45
PTGS2 P35354 1/20 0.45
CNR2 P34972 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8421921 0.88 CA2 (0.44) CNR1PTGS1PTGS2CNR2
SCHEMBL8423893 0.86 CNR1 (0.41) CNR1PTGS1PTGS2CNR2
SCHEMBL8423990 0.85 CNR1 (0.40) CNR1PTGS1PTGS2CNR2
SCHEMBL8424012 0.85 PTGS1 (0.42) CNR1PTGS1PTGS2CNR2
SCHEMBL8421702 0.85 PTGS1 (0.47) CNR1PTGS1PTGS2CNR2
SCHEMBL8422208 0.84 CNR1 (0.39) CNR1PTGS1PTGS2CNR2
SCHEMBL8640287 0.84 PTGS2 (0.66) CNR1PTGS1PTGS2
SCHEMBL8420780 0.84 CHRNA7 (0.40) CNR1PTGS1PTGS2CNR2
SCHEMBL8421959 0.83 CA12 (0.43) CNR1PTGS1PTGS2CNR2
SCHEMBL8420775 0.83 CNR1 (0.41) CNR1PTGS1PTGS2CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5908852-A 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation G. D. SEARLE & CO. (US) 1999-06-01 US disclosed