Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7338415 | 0.84 | SNCA (0.49) | SNCAHIF1AALDH1A1SIGMAR1MAPK1 | |
| Hydrochloric Acid SCHEMBL5972958 | 0.84 | SNCA (0.49) | SNCAHIF1AMAPTGAACYP3A4 | |
| Bromide SCHEMBL4165247 | 0.81 | SNCA (0.51) | SNCAHIF1AMAPTGAACYP3A4 | |
| Bromide SCHEMBL1508970 | 0.81 | SNCA (0.51) | SNCAHIF1AALDH1A1SIGMAR1MAPK1 | |
| Hydrochloric Acid SCHEMBL27527607 | 0.78 | PNMT (0.43) | SNCAHIF1APNMT | |
| Bromide SCHEMBL1508663 | 0.77 | SNCA (0.47) | SNCAHIF1ACYP3A4DRD4RAB9A | |
| Bromide SCHEMBL10721589 | 0.76 | MEN1 (0.47) | SNCAKDM1AALDH1A1MAPTGAA | |
| Hydrochloric Acid SCHEMBL9714762 | 0.76 | TSHR (0.42) | SNCAHIF1AALDH1A1GAANPSR1 | |
| Hydrochloric Acid SCHEMBL9303546 | 0.75 | PNMT (0.49) | ALDH1A1MAPTGAASIGMAR1PNMT | |
| Hydrochloric Acid SCHEMBL2446696 | 0.75 | SNCA (0.69) | SNCAHIF1AALDH1A1CYP3A4SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0949238-A1 | SUBSTITUTED PROPIONYL DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1999-10-13 | — | — | EP | disclosed |