Phenformin

Phenformin

SCHEMBL8425

NC(N)=N/C(N)=N/CCc1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 1.00
HIF1A Q16665 3/20 1.00
TSHR P16473 2/20 1.00
SLC22A2 O15244 1/20 1.00
SLC22A1 O15245 1/20 1.00
ADRA2A P08913 1/20 1.00
CYP2D6 P10635 1/20 1.00
ADRA2B P18089 1/20 1.00
SLC6A2 P23975 1/20 1.00
ADRA1A P35348 1/20 1.00
HTR2B P41595 1/20 1.00
SLC6A3 Q01959 1/20 1.00
PDE3A Q14432 1/20 1.00
MAPT P10636 1/20 0.96
SMN1; SMN2 Q16637 1/20 0.96
TDP1 Q9NUW8 1/20 0.96
CA12 O43570 2/20 0.61
CA1 P00915 2/20 0.61
CA2 P00918 2/20 0.61
CA9 Q16790 2/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenformin SCHEMBL10325620 1.00 LMNA (1.00) LMNAHIF1ATSHRSLC22A2SLC22A1
Phenformin SCHEMBL136512 1.00 LMNA (1.00) LMNAHIF1ATSHRSLC22A2SLC22A1
Phenformin SCHEMBL787929 0.96 LMNA (0.93) LMNAHIF1ATSHRSLC22A2SLC22A1
SCHEMBL19770321 0.85 HIF1A (0.74) LMNAHIF1ATSHRSLC22A2SLC22A1
SCHEMBL28524333 0.85 HIF1A (0.74) LMNAHIF1ATSHRSLC22A2SLC22A1
[11C]Phenethylguanidine SCHEMBL837645 0.84 HTR3A (0.80) LMNAHIF1ATSHRSLC22A2SLC22A1
SCHEMBL23366564 0.81 TSHR (0.69) LMNAHIF1ATSHRSLC22A2SLC22A1
SCHEMBL1736064 0.80 TAAR1 (0.67) LMNAHIF1ATSHRSLC22A2SLC22A1
SCHEMBL1736065 0.80 TAAR1 (0.67) LMNAHIF1ATSHRSLC22A2SLC22A1
[11C]Phenethylguanidine SCHEMBL28305963 0.78 HTR3A (0.71) LMNAHIF1ATSHRSLC22A2SLC22A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 21356 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122079768-A Method for selectively and efficiently depolymerizing and recycling PET in waste blended fabric 2026-05-26 CN claimed
EP-3956809-B1 IMAGE PROCESSING METHOD FOR AN IDENTITY DOCUMENT SURYS (FR) 2026-05-06 EP claimed
EP-4499765-B1 COMPOSITIONS AND METHODS FOR TUNGSTEN ETCHING INHIBITION BASF SE (DE) 2026-05-06 EP claimed
US-12605354-B2 Azelaic acid esters in the treatment or prevention of dyslipidemia and associated conditions NEW FRONTIER LABS, LLC (US) 2026-04-21 US claimed
US-20260076969-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2026-03-19 US claimed
EP-4243366-B1 NETWORK MONITORING AND TROUBLESHOOTING USING AUGMENTED REALITY JUNIPER NETWORKS INC (US) 2026-02-25 EP claimed
EP-4103445-B1 SYSTEM AND METHOD FOR RAIL SCANNING USING ELECTROMAGNETIC ENGINES HYPERLOOP TECH INC (US) 2026-02-18 EP claimed
US-20260028334-A1 N-(3-(BENZO[B]THIOPHENE-2-CARBOXAMIDO)-PHENYL)-2,3-DIHYDROBENZO[B][1,4]DIOXINE-6-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS LACTATE/ATP PRODUCTION INHIBITORS FOR THE TREATMENT OF CANCER WMT AG (DE) 2026-01-29 US claimed
EP-4684799-A2 ANTIBODIES THAT DISRUPT THE INTERACTION OF GAL3 AND INSULIN RECEPTOR OR INTEGRINS AND METHODS OF USE THEREOF TrueBinding, Inc. (US) 2026-01-28 EP claimed
US-20250360215-A1 PHARMACEUTICAL COMBINATIONS AND METHODS FOR PREVENTING OR TREATING NEURODEGENERATIVE DISEASES YUH CHIOU HWA (US) 2025-11-27 US claimed
EP-0019423-B1 PHARMACEUTICAL AND DIETARY COMPOSITION COMPRISING GAMMA-LINOLENIC ACIDS EFAMOL LIMITED (GB) 1984-06-13 EP claimed
EP-0078434-A1 Pharmaceutical and dietary compositions EFAMOL LIMITED (GB) 1983-05-11 EP claimed
US-4346709-A Drug delivery devices comprising erodible polymer and erosion rate modifier ALZA CORPORATION (US) 1982-08-31 US claimed
US-4309415-A LINOLENIC ACID OR DERIVATIVE WITH MATERIAL WHICH ENHANCES BIOSYNTHESIS OF THROMBOXANE A2 VERRONMAY LIMITED (GB) 1982-01-05 US claimed
EP-0037175-A1 Pharmaceutical compositions EFAMOL LIMITED (GB) 1981-10-07 EP claimed
EP-0035856-A2 Pharmaceutical and dietary compositions EFAMOL LIMITED (GB) 1981-09-16 EP claimed
US-4254108-A ALDOSE REDUCTASE INHIBITORS AYERST, MCKENNA & HARRISON INC. (CA) 1981-03-03 US claimed
US-4254109-A INHIBIT LENS ALDOSE REDUCTASE AYERST, MCKENNA & HARRISON INC. (CA) 1981-03-03 US claimed
EP-0019423-A1 Pharmaceutical and dietary composition comprising gamma-linolenic acids EFAMOL LIMITED (GB) 1980-11-26 EP claimed
EP-0004770-A2 Pharmaceutical and dietary composition comprising gamma-linolenic acids EFAMOL LIMITED (GB) 1979-10-17 EP claimed