Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 5/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | KLK7 | P49862 | 3/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14408099 | 1.00 | FKBP1A (0.45) | FKBP1ACTSLKLK7KLK5GPR119 | |
| SCHEMBL31486499 | 0.89 | CTSL (0.44) | FKBP1ACTSLKLK7KLK5STS | |
| SCHEMBL9198129 | 0.88 | FKBP1A (0.45) | FKBP1ACTSLKLK7STS | |
| SCHEMBL31107722 | 0.88 | FKBP1A (0.45) | FKBP1ACTSLKLK7STS | |
| SCHEMBL31486416 | 0.86 | FKBP1A (0.45) | FKBP1ACTSLKLK7 | |
| SCHEMBL31486292 | 0.86 | FKBP1A (0.45) | FKBP1ACTSLKLK7 | |
| SCHEMBL22446555 | 0.84 | KLK7 (0.45) | FKBP1ACTSLKLK7KLK5 | |
| SCHEMBL31486301 | 0.84 | FKBP1A (0.44) | FKBP1ACTSLKLK7KLK5 | |
| SCHEMBL12643706 | 0.84 | KLK7 (0.45) | FKBP1ACTSLKLK7KLK5 | |
| SCHEMBL31107821 | 0.84 | FKBP1A (0.44) | FKBP1ACTSLKLK7ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143416-B2 | Alternative synthesis of renin inhibitors and intermediates thereof | NOVARTIS AG (CH) | 2012-03-27 | — | — | US | disclosed |
| US-8143416-B2 | Alternative synthesis of renin inhibitors and intermediates thereof | NOVARTIS AG (CH) | 2012-03-27 | — | — | US | disclosed |
| US-20110137044-A1 | ALTERNATIVE SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES THEREOF | NOVARTIS AG (CH) | 2011-06-09 | — | — | US | disclosed |
| US-20110137044-A1 | ALTERNATIVE SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES THEREOF | NOVARTIS AG (CH) | 2011-06-09 | — | — | US | disclosed |
| US-7910774-B2 | Alternative synthesis of renin inhibitors and intermediates thereof | NOVARTIS AG (CH) | 2011-03-22 | — | — | US | disclosed |
| US-7910774-B2 | Alternative synthesis of renin inhibitors and intermediates thereof | NOVARTIS AG (CH) | 2011-03-22 | — | — | US | disclosed |
| EP-1789377-B1 | ALTERNATIVE SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES THEREOF | NOVARTIS AG (CH) | 2010-10-20 | — | — | EP | disclosed |
| US-20070208055-A1 | ALTERNATIVE SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES THEREOF | NOVARTIS AG (CH) | 2007-09-06 | — | — | US | disclosed |
| US-20070208055-A1 | ALTERNATIVE SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES THEREOF | NOVARTIS AG (CH) | 2007-09-06 | — | — | US | disclosed |
| WO-2006024501-A1 | ALTERNATIVE SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES THEREOF | NOVARTIS AG (CH) | 2006-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110137044-A1 | ALTERNATIVE SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES THEREOF | REN, ACE, AGT | FKBP1A 3655/4885CTSL 58/4885KLK7 190/4885 |
| US-20070208055-A1 | ALTERNATIVE SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES THEREOF | REN, ACE, AGT | FKBP1A 3708/4885CTSL 54/4885KLK7 184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.