SCHEMBL84258

SCHEMBL84258

Nc1nc2c(c(=O)[nH]1)NCN2CC(CO)OCP(=O)(O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HPRT1 P00492 14/20 1.00
FGFR1 P11362 1/20 0.45
SLC22A6 Q4U2R8 1/20 0.44
TYMP P19971 2/20 0.44
MEN1 O00255 1/20 0.36
ALDH1A1 P00352 1/20 0.36
LMNA P02545 1/20 0.36
CYP3A4 P08684 1/20 0.36
NFKB1 P19838 1/20 0.36
BLM P54132 1/20 0.36
VCP P55072 1/20 0.36
KMT2A Q03164 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
HIF1A Q16665 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9189461 0.91 HPRT1 (1.00) HPRT1FGFR1SLC22A6TYMP
SCHEMBL9055682 0.90 HPRT1 (0.81) HPRT1FGFR1SLC22A6TYMPMEN1
SCHEMBL4713155 0.86 HPRT1 (0.76) HPRT1TYMPCYP3A4
SCHEMBL28646181 0.86 HPRT1 (0.75) HPRT1MEN1ALDH1A1LMNACYP3A4
SCHEMBL9417241 0.85 HPRT1 (0.74) HPRT1FGFR1SLC22A6TYMPMEN1
SCHEMBL8896070 0.85 HPRT1 (0.74) HPRT1FGFR1SLC22A6MEN1ALDH1A1
Phosphoric Acid SCHEMBL15054256 0.85 HPRT1 (0.74) HPRT1TYMPCYP3A4
SCHEMBL28513633 0.84 HPRT1 (0.72) HPRT1MEN1ALDH1A1LMNACYP3A4
SCHEMBL9054484 0.83 HPRT1 (0.71) HPRT1
SCHEMBL8752240 0.83 HPRT1 (0.71) HPRT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 127 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6964968-B2 Method for the treatment or prevention of viral infection using nucleoside analogues SHIRE BIOCHEM, INC. (CA) 2005-11-15 US claimed
US-6583149-B1 2-hydroxymethyl-4-(cytosin-1'-yl)-1,3-Dioxolane BIOCHEM PHARMA INC. (CA) 2003-06-24 US claimed
US-12403291-B2 Submucosal bioresorbable drug eluting platform INTERSECT ENT, INC. (US) 2025-09-02 US disclosed
US-20240269350-A1 IMPLANTABLE MATRIX FOR TREATING CENTRAL NERVOUS SYSTEM DISORDERS LYRA THERAPEUTICS, INC. 2024-08-15 US disclosed
US-20230389690-A1 PERSONAL CLEANSING WAND Silicon Valley Innovations, Inc. 2023-12-07 US disclosed
EP-4225168-A1 PERSONAL CLEANSING WAND Silicon Valley Innovations, Inc. (US) 2023-08-16 EP disclosed
EP-4221645-A1 OSMOTIC DRUG DELIVERY IMPLANTS Lyra Therapeutics, Inc. (US) 2023-08-09 EP disclosed
US-20230233451-A1 OSMOTIC DRUG DELIVERY IMPLANTS LYRA THERAPEUTICS, INC. 2023-07-27 US disclosed
US-11684146-B2 Personal cleansing wand Silicon Valley Innovations, Inc. (US) 2023-06-27 US disclosed
US-11672959-B2 Expandable member systems and methods for drug delivery INTERSECT ENT, INC. (US) 2023-06-13 US disclosed
US-11654216-B2 Self-expanding devices and methods therefor INTERSECT ENT, INC. (US) 2023-05-23 US disclosed
EP-0897917-A1 Compounds for use in the preparation of antiretroviral enantiomeric nucleotide analogs INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1999-02-24 EP disclosed
US-5854228-A Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1998-12-29 US disclosed
US-5650510-A VIRICIDES OR ANTITUMOR AGENTS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-07-22 US disclosed
EP-0452935-B1 Chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents ACAD OF SCIENCE CZECH REPUBLIC (CS) 1995-06-21 EP disclosed
EP-0654037-A1 ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1995-05-24 EP disclosed
US-5302585-A Viricides, HIV virus INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CS) 1994-04-12 US disclosed
WO-1994003467-A2 ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1994-02-17 WO disclosed
EP-0452935-A1 Chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CS) 1991-10-23 EP disclosed
EP-0269947-A1 Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CS) 1988-06-08 EP disclosed