Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.57 |
| ▸ | DRD3 | P35462 | 2/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.55 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8425898 | 1.00 | DRD2 (0.57) | DRD2DRD3OPRM1PRMT5KDM4E | |
| SCHEMBL8426178 | 0.94 | DRD2 (0.63) | DRD2DRD3OPRM1PRMT5KDM4E | |
| SCHEMBL8426184 | 0.94 | DRD2 (0.63) | DRD2DRD3OPRM1PRMT5KDM4E | |
| SCHEMBL8426019 | 0.93 | DRD3 (0.67) | DRD2DRD3OPRM1PRMT5LMNA | |
| SCHEMBL8426018 | 0.93 | DRD3 (0.67) | DRD2DRD3OPRM1PRMT5LMNA | |
| SCHEMBL8333009 | 0.89 | DRD2 (0.50) | DRD2DRD3OPRM1PRMT5KDM4E | |
| SCHEMBL8333005 | 0.89 | DRD2 (0.50) | DRD2DRD3OPRM1PRMT5KDM4E | |
| SCHEMBL9263247 | 0.87 | PRMT5 (0.59) | DRD2DRD3PRMT5KDM4EWDR77 | |
| SCHEMBL9263228 | 0.87 | PRMT5 (0.59) | DRD2DRD3PRMT5KDM4EWDR77 | |
| SCHEMBL8424360 | 0.85 | PRMT5 (0.46) | DRD2DRD3OPRM1PRMT5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995021832-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-08-17 | — | — | WO | claimed |
| US-5891877-A | INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR | XENOVA LIMITED (GB) | 1999-04-06 | — | — | US | disclosed |
| WO-1995021832-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-08-17 | — | — | WO | disclosed |