Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 6/20 | 0.59 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9263228 | 1.00 | PRMT5 (0.59) | PRMT5WDR77HDAC3HDAC1HDAC8 | |
| SCHEMBL8425898 | 0.87 | DRD2 (0.57) | PRMT5WDR77KDM4EDRD2DRD3 | |
| SCHEMBL8425893 | 0.87 | DRD2 (0.57) | PRMT5WDR77KDM4EDRD2DRD3 | |
| SCHEMBL8426178 | 0.85 | DRD2 (0.63) | PRMT5WDR77KDM4EDRD2DRD3 | |
| SCHEMBL8426184 | 0.85 | DRD2 (0.63) | PRMT5WDR77KDM4EDRD2DRD3 | |
| SCHEMBL8426019 | 0.84 | DRD3 (0.67) | PRMT5WDR77DRD2DRD3HTR1A | |
| SCHEMBL8426018 | 0.84 | DRD3 (0.67) | PRMT5WDR77DRD2DRD3HTR1A | |
| SCHEMBL8333005 | 0.77 | DRD2 (0.50) | PRMT5WDR77KDM4EALOX15DRD2 | |
| SCHEMBL8333009 | 0.77 | DRD2 (0.50) | PRMT5WDR77KDM4EALOX15DRD2 | |
| SCHEMBL8425003 | 0.76 | ABCG2 (0.78) | KDM4EMEN1KMT2ASMN1; SMN2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995021832-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-08-17 | — | — | WO | claimed |