Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3059418 | 0.81 | ALDH1A1 (0.72) | ALDH1A1TSHRHSD17B10MAPK1L3MBTL1 | |
| SCHEMBL2175455 | 0.78 | ALDH1A1 (0.63) | ALDH1A1TSHRHSD17B10MAPK1L3MBTL1 | |
| SCHEMBL8426538 | 0.75 | L3MBTL1 (0.46) | ALDH1A1HSD17B10MAPK1L3MBTL1RAB9A | |
| SCHEMBL18343662 | 0.74 | ALDH1A1 (0.67) | ALDH1A1TSHRHSD17B10MAPK1L3MBTL1 | |
| SCHEMBL8116420 | 0.74 | ALDH1A1 (0.55) | ALDH1A1TSHRHSD17B10MAPK1L3MBTL1 | |
| SCHEMBL8107490 | 0.73 | ALDH1A1 (0.77) | ALDH1A1TSHRHSD17B10MAPK1L3MBTL1 | |
| SCHEMBL15555582 | 0.73 | ALDH1A1 (0.75) | ALDH1A1TSHRHSD17B10MAPK1L3MBTL1 | |
| SCHEMBL12786989 | 0.73 | ALDH1A1 (0.75) | ALDH1A1TSHRHSD17B10MAPK1L3MBTL1 | |
| SCHEMBL3583405 | 0.73 | ALDH1A1 (1.00) | ALDH1A1TSHRHSD17B10MAPK1RAB9A | |
| SCHEMBL3583770 | 0.73 | ALDH1A1 (0.69) | ALDH1A1TSHRHSD17B10MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-11180975-A | — | — | None | — | — | JP | disclosed |
| EP-3453704-B1 | PHENOL COMPOUND AND COMBINATION OF SAME WITH A BENZODIAZEPINE FUSED TO 1,4-DIHYDROPYRIDINE FOR TREATING DISEASES OF THE CENTRAL NERVOUS AND VASCULAR SYSTEMS | UNIV LA HABANA (CU) | 2021-06-16 | — | — | EP | disclosed |
| CN-109476627-B | Phenolic compounds and combinations thereof with benzodiazepines fused to 1, 4-dihydropyridines for the treatment of pathologies of the central nervous system and of the vascular system | 哈瓦那大学 | 2021-06-15 | — | — | CN | disclosed |
| US-10722491-B2 | Phenol compound and combination of same with a benzodiazepine fused to 1,4-dihydropyridine for treating diseases of the central nervous and vascular systems | UNIVERSIDAD DE LA HABANA (CU) | 2020-07-28 | — | — | US | disclosed |
| US-20190133996-A1 | PHENOL COMPOUND AND COMBINATION OF SAME WITH A BENZODIAZEPINE FUSED TO 1,4-DIHYDROPYRIDINE FOR TREATING DISEASES OF THE CENTRAL NERVOUS AND VASCULAR SYSTEMS | UNIVERSIDAD DE LA HABANA (CU) | 2019-05-09 | — | — | US | disclosed |
| EP-3453704-A1 | PHENOL COMPOUND AND COMBINATION OF SAME WITH A BENZODIAZEPINE FUSED TO 1,4-DIHYDROPYRIDINE FOR TREATING DISEASES OF THE CENTRAL NERVOUS AND VASCULAR SYSTEMS | Universidad de La Habana (CU) | 2019-03-13 | — | — | EP | disclosed |
| JP-H11180975-A | AMINOMETHYLENE DIOXANE DERIVATIVE, ITS PRODUCTION AND USE THEREOF | CHEMIPROKASEI KAISHA LTD | 1999-07-06 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10722491-B2 | Phenol compound and combination of same with a benzodiazepine fused to 1,4-dihydropyridine for treating diseases of the central nervous and vascular systems | PPARG, PPARD, CACNA1G | ALDH1A1 1169/4885TSHR 3976/4885HSD17B10 1361/4885 |
| US-20190133996-A1 | PHENOL COMPOUND AND COMBINATION OF SAME WITH A BENZODIAZEPINE FUSED TO 1,4-DIHYDROPYRIDINE FOR TREATING DISEASES OF THE CENTRAL NERVOUS AND VASCULAR SYSTEMS | PPARG, PPARD, CACNA1G | ALDH1A1 1169/4885TSHR 3976/4885HSD17B10 1361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.