Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 1/20 | 0.61 |
| ▸ | FNTB | P49356 | 1/20 | 0.61 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.56 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.56 |
| ▸ | ITGAL | P20701 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.54 |
| ▸ | HTR1A | P08908 | 4/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.54 |
| ▸ | DRD2 | P14416 | 4/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8426332 | 0.94 | FNTA (0.61) | FNTAFNTBITGB2ICAM1ITGAL | |
| SCHEMBL8435143 | 0.91 | FNTA (0.66) | FNTAFNTBITGB2ICAM1ITGAL | |
| SCHEMBL8430522 | 0.89 | MAPT (0.63) | FNTAFNTBMAPTLMNAKDM1A | |
| SCHEMBL8426449 | 0.82 | BCHE (0.64) | FNTAFNTBMAPTLMNAKDM1A | |
| SCHEMBL8430635 | 0.81 | FNTA (0.55) | FNTAFNTBITGB2ICAM1ITGAL | |
| SCHEMBL6843471 | 0.81 | LMNA (0.76) | FNTAFNTBITGB2ICAM1ITGAL | |
| SCHEMBL8520671 | 0.81 | ITGB2 (0.62) | FNTAFNTBITGB2ICAM1ITGAL | |
| SCHEMBL14292499 | 0.80 | ITGB2 (0.72) | ITGB2ICAM1ITGALMAPTLMNA | |
| SCHEMBL27083994 | 0.80 | ITGB2 (0.69) | FNTAFNTBITGB2ICAM1ITGAL | |
| SCHEMBL15908318 | 0.80 | LMNA (0.62) | ITGB2ICAM1ITGALMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861394-A | COMPOUNDS AS ANTIISCHEMIC AGENTS, TREATMENT OF STROKES, ANTIHEMORRHEGENIC AGENTS, ANTIDEPRESSANTS OR TREATMENT OF SICKKLE CELL ANEMIA | BAYER AKTIENGESELLSCHAFT (DE) | 1999-01-19 | — | — | US | claimed |
| EP-0777481-A1 | USE OF N-SUBSTITUTED PHENOTHIAZINES | BAYER AG (DE) | 1997-06-11 | — | — | EP | claimed |
| WO-1996005837-A1 | USE OF N-SUBSTITUTED PHENOTHIAZINES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-02-29 | — | — | WO | claimed |