Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 3/20 | 0.55 |
| ▸ | FNTB | P49356 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.49 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.49 |
| ▸ | ITGAL | P20701 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8435143 | 0.83 | FNTA (0.66) | FNTAFNTBTSHRHDAC3HDAC4 | |
| SCHEMBL8426650 | 0.81 | FNTA (0.61) | FNTAFNTBTSHRHDAC3HDAC4 | |
| SCHEMBL8426332 | 0.79 | FNTA (0.61) | FNTAFNTBTSHRITGB2ICAM1 | |
| SCHEMBL8520671 | 0.78 | ITGB2 (0.62) | FNTAFNTBTSHRHDAC3HDAC4 | |
| SCHEMBL6843471 | 0.78 | LMNA (0.76) | FNTAFNTBTSHRHDAC3HDAC4 | |
| SCHEMBL27083994 | 0.74 | ITGB2 (0.69) | FNTAFNTBTSHRITGB2ICAM1 | |
| SCHEMBL8869747 | 0.73 | LMNA (0.64) | TSHRITGB2ICAM1ITGALTDP1 | |
| SCHEMBL14697664 | 0.73 | LMNA (0.60) | TSHRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL27083995 | 0.72 | CYP2D6 (0.65) | TSHRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6637375 | 0.72 | LMNA (0.74) | TSHRHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861394-A | COMPOUNDS AS ANTIISCHEMIC AGENTS, TREATMENT OF STROKES, ANTIHEMORRHEGENIC AGENTS, ANTIDEPRESSANTS OR TREATMENT OF SICKKLE CELL ANEMIA | BAYER AKTIENGESELLSCHAFT (DE) | 1999-01-19 | — | — | US | claimed |
| EP-0777481-A1 | USE OF N-SUBSTITUTED PHENOTHIAZINES | BAYER AG (DE) | 1997-06-11 | — | — | EP | claimed |
| WO-1996005837-A1 | USE OF N-SUBSTITUTED PHENOTHIAZINES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-02-29 | — | — | WO | claimed |