Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8533206 | 0.87 | TRPV1 (0.51) | TRPV1MTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL9293943 | 0.87 | TRPV1 (0.51) | TRPV1MTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL8533704 | 0.81 | TRPV1 (0.54) | TRPV1MTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL8427317 | 0.79 | TLR8 (0.37) | TRPV1TLR9TLR8TLR7ROCK2 | |
| SCHEMBL8427434 | 0.79 | TRPV1 (0.45) | TRPV1MEN1KMT2A | |
| SCHEMBL159361 | 0.74 | — | — | |
| SCHEMBL8532835 | 0.74 | — | — | |
| SCHEMBL9669803 | 0.73 | KMT2A (0.46) | TRPV1MTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL8423638 | 0.72 | — | — | |
| SCHEMBL8422975 | 0.72 | SNCA (0.46) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863873-B1 | INDOLE CARBAMATES AS LEUKOTRIENE ANTAGONISTS | PFIZER (US) | 1999-11-10 | — | — | EP | disclosed |
| US-5965745-A | ASTHMA; ANTIARTHRITIC,-SHOCK AGENTS; BRONCHITIS; RESPIRATORY SYSTEM DISEASES, E.G. CHRONIC OBSTRUCTIVE AIRWAYS DISEASES; PSORIASIS; ALLERGIC RHINITIS; ATOPIC DERMATITIS | PFIZER INC (US) | 1999-10-12 | — | — | US | disclosed |