⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8532662 | 0.87 | — | — | |
| SCHEMBL9293941 | 0.87 | — | — | |
| SCHEMBL8427210 | 0.86 | — | — | |
| SCHEMBL8533700 | 0.81 | — | — | |
| SCHEMBL8427434 | 0.78 | TRPV1 (0.45) | — | |
| SCHEMBL8427410 | 0.72 | TRPV1 (0.46) | — | |
| SCHEMBL9669798 | 0.71 | CPT2 (0.54) | — | |
| SCHEMBL9633859 | 0.70 | — | — | |
| SCHEMBL8536461 | 0.69 | PLA2G4A (0.61) | — | |
| SCHEMBL8533206 | 0.68 | TRPV1 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863873-B1 | INDOLE CARBAMATES AS LEUKOTRIENE ANTAGONISTS | PFIZER (US) | 1999-11-10 | — | — | EP | disclosed |
| US-5965745-A | ASTHMA; ANTIARTHRITIC,-SHOCK AGENTS; BRONCHITIS; RESPIRATORY SYSTEM DISEASES, E.G. CHRONIC OBSTRUCTIVE AIRWAYS DISEASES; PSORIASIS; ALLERGIC RHINITIS; ATOPIC DERMATITIS | PFIZER INC (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0863873-A1 | INDOLE CARBAMATES AS LEUKOTRIENE ANTAGONISTS | PFIZER INC. (US) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997013751-A1 | INDOLE CARBAMATES AS LEUKOTRIENE ANTAGONISTS | PFIZER INC. (US) | 1997-04-17 | — | — | WO | disclosed |