SCHEMBL8428409

SCHEMBL8428409

Cc1cn(-c2cccc(C(F)(F)F)c2)c(=NC(=O)C(F)Cl)s1

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 5/20 0.43
NOTUM Q6P988 1/20 0.39
SCN2B O60939 2/20 0.38
SCN1B Q07699 2/20 0.38
SCN5A Q14524 2/20 0.38
SCN9A Q15858 2/20 0.38
SCN1A P35498 1/20 0.38
HTT P42858 1/20 0.37
POLB P06746 1/20 0.36
NPY5R Q15761 4/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
ALDH1A1 P00352 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8424239 0.91 CNR2 (0.44) CNR2NOTUMSCN2BSCN1BSCN5A
SCHEMBL8425725 0.90 CNR2 (0.43) CNR2NOTUMSCN2BSCN1BSCN5A
SCHEMBL8428185 0.88 CNR2 (0.39) CNR2NOTUMSCN2BSCN1BSCN5A
SCHEMBL8425428 0.88 CNR2 (0.43) CNR2NOTUMSCN2BSCN1BSCN5A
SCHEMBL8423321 0.87 MAPT (0.39) CNR2NOTUMSCN2BSCN1BSCN5A
SCHEMBL8428107 0.86 PKM (0.37) CNR2NOTUMSCN2BSCN1BSCN5A
SCHEMBL8424057 0.86 CNR2 (0.39) CNR2NOTUMSCN2BSCN1BSCN5A
SCHEMBL9064537 0.85 CNR2 (0.49) CNR2NOTUMSCN2BSCN1BSCN5A
SCHEMBL8424571 0.85 CNR1 (0.38) CNR2NOTUMPOLBNPY5R
SCHEMBL9064654 0.84 CNR2 (0.46) CNR2NOTUMSCN2BSCN1BSCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0636616-B1 Process for production of fluoroalkanecarboxamide derivatives SUMITOMO CHEMICAL CO (JP) 1999-10-27 EP disclosed
US-5484933-A Process for production of fluoroalkane carboxamide derivatives SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-01-16 US disclosed
EP-0636616-A1 Process for production of fluoroalkanecarboxamide derivatives SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-02-01 EP disclosed