SCHEMBL8424571

SCHEMBL8424571

Cc1cn(-c2cccc(OC(F)(F)F)c2)c(=NC(=O)C(F)Cl)s1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 1/20 0.38
CNR2 P34972 1/20 0.38
LMNA P02545 1/20 0.36
POLB P06746 1/20 0.36
NOTUM Q6P988 1/20 0.36
NPY5R Q15761 1/20 0.36
CCKAR P32238 1/20 0.35
KCNQ3 O43525 6/20 0.35
KCNQ2 O43526 6/20 0.35
CTSA P10619 2/20 0.35
KCNH2 Q12809 2/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
ACACB O00763 1/20 0.34
RXRA P19793 1/20 0.34
GRIN1 Q05586 1/20 0.34
GRIN2B Q13224 1/20 0.34
GPR142 Q7Z601 1/20 0.33
DRD2 P14416 1/20 0.33
DRD3 P35462 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8424553 0.92 CNR1 (0.39) CNR1CNR2LMNAPOLBNOTUM
SCHEMBL8427939 0.91 CNR1 (0.38) CNR1CNR2NOTUMNPY5RCCKAR
SCHEMBL8425765 0.90 RAB9A (0.40) LMNANPC1RAB9ARXRAGRIN1
SCHEMBL9083666 0.88 CNR1 (0.40) CNR1CNR2NOTUMNPY5RCCKAR
SCHEMBL8428409 0.85 CNR2 (0.43) CNR2POLBNOTUMNPY5R
SCHEMBL8428107 0.85 PKM (0.37) CNR2POLBNOTUMNPC1RAB9A
SCHEMBL8428131 0.83 NPC1 (0.40) CNR1CNR2LMNANPC1RAB9A
SCHEMBL8428211 0.82 NPC1 (0.39) CNR1CNR2LMNANPC1RAB9A
SCHEMBL8425430 0.81 NPC1 (0.42) LMNANPC1RAB9ARXRAGRIN1
SCHEMBL2840721 0.80 CCKAR (0.40) CNR1CNR2NOTUMCCKARKCNQ3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0636616-B1 Process for production of fluoroalkanecarboxamide derivatives SUMITOMO CHEMICAL CO (JP) 1999-10-27 EP disclosed
US-5484933-A Process for production of fluoroalkane carboxamide derivatives SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-01-16 US disclosed
EP-0636616-A1 Process for production of fluoroalkanecarboxamide derivatives SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-02-01 EP disclosed