Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL7757156 | 0.98 | — | — | |
| Histidine SCHEMBL7759763 | 0.97 | GSR (0.32) | GHSR | |
| Histidine SCHEMBL6554652 | 0.96 | — | — | |
| Histidine SCHEMBL8428513 | 0.95 | — | — | |
| Histidine SCHEMBL20817128 | 0.93 | — | — | |
| Histidine SCHEMBL28798985 | 0.92 | GSR (0.32) | — | |
| Histidine SCHEMBL7753923 | 0.92 | SLC7A5 (0.30) | — | |
| Histidine SCHEMBL27684219 | 0.89 | SLC7A5 (0.34) | — | |
| Histidine SCHEMBL28633479 | 0.88 | — | — | |
| Histidine SCHEMBL23831122 | 0.87 | GSR (0.39) | GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0955311-A2 | Peptide vaccine for canine allergy | IDEXX LABORATORIES, INC. (US) | 1999-11-10 | — | — | EP | claimed |