Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL7753923 | 0.92 | SLC7A5 (0.30) | — | |
| Histidine SCHEMBL7757156 | 0.91 | — | — | |
| Histidine SCHEMBL6554652 | 0.89 | — | — | |
| Histidine SCHEMBL27684219 | 0.89 | SLC7A5 (0.34) | — | |
| Histidine SCHEMBL19809592 | 0.89 | — | — | |
| Histidine SCHEMBL29087098 | 0.88 | REN (0.30) | — | |
| Histidine SCHEMBL7763229 | 0.88 | — | — | |
| Leucine SCHEMBL28337257 | 0.88 | SLC7A5 (0.35) | — | |
| Histidine SCHEMBL8428516 | 0.88 | GHSR (0.30) | — | |
| Phenylalanine SCHEMBL294178 | 0.88 | REN (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113214358-B | Short peptide, detection kit and method for detecting vascular endothelial growth factor | 青岛大学 | 2022-03-15 | — | — | CN | disclosed |
| CN-113214358-A | Short peptide, detection kit and method for detecting vascular endothelial growth factor | 青岛大学 | 2021-08-06 | — | — | CN | disclosed |