Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL6554652 | 0.99 | — | — | |
| Histidine SCHEMBL8428516 | 0.98 | GHSR (0.30) | — | |
| Histidine SCHEMBL20817128 | 0.95 | — | — | |
| Histidine SCHEMBL28798985 | 0.95 | GSR (0.32) | — | |
| Histidine SCHEMBL7759763 | 0.95 | GSR (0.32) | — | |
| Histidine SCHEMBL8428513 | 0.93 | — | — | |
| Histidine SCHEMBL28633479 | 0.91 | — | — | |
| Histidine SCHEMBL7753923 | 0.90 | SLC7A5 (0.30) | — | |
| Histidine SCHEMBL7757149 | 0.89 | — | — | |
| Arginine SCHEMBL6040161 | 0.88 | TUBB4A (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082346-A1 | SPECIFIC BINDING PROTEINS FOR TREATING CANINE ALLERGY | IDEXX LABORATORIES, INC. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-2000058365-A1 | SPECIFIC BINDING PROTEINS FOR TREATING CANINE ALLERGY | IDEXX LABORATORIES, INC. (US) | 2000-10-05 | — | — | WO | disclosed |