Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL20817128 | 0.97 | — | — | |
| Histidine SCHEMBL7757156 | 0.95 | — | — | |
| Histidine SCHEMBL6554652 | 0.94 | — | — | |
| Histidine SCHEMBL8428516 | 0.92 | GHSR (0.30) | — | |
| Dl-Phenylalanine SCHEMBL20681705 | 0.92 | GHSR (0.32) | — | |
| Histidine SCHEMBL23831122 | 0.90 | GSR (0.39) | GSR | |
| D-Histidine SCHEMBL11414815 | 0.90 | GSR (0.39) | GSR | |
| Histidine SCHEMBL18297983 | 0.90 | GSR (0.39) | GSR | |
| Histidine SCHEMBL7759763 | 0.89 | GSR (0.32) | GSR | |
| Histidine SCHEMBL8428513 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102533634-A | Serum-free protein-free chemical culture medium for Chinese hamster ovary (CHO) cells | JIANGYIN JIANQIAO BIOLOG TECHNOLOGY CO LTD | 2012-07-04 | — | — | CN | disclosed |