Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | XPO1 | O14980 | 1/20 | 0.37 |
| ▸ | JUN | P05412 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | P2RX1 | P51575 | 5/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.35 |
| ▸ | TMPRSS4 | Q9NRS4 | 4/20 | 0.35 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8333007 | 0.99 | GPR35 (0.37) | GPR35GAAXPO1JUNNFKB1 | |
| SCHEMBL8428562 | 0.85 | GPR35 (0.35) | GPR35GAAXPO1JUNNFKB1 | |
| SCHEMBL8430498 | 0.84 | GPR35 (0.36) | GPR35GAAXPO1JUNNFKB1 | |
| SCHEMBL8426327 | 0.84 | MAPT (0.40) | GPR35P2RX1TMPRSS4MEN1KMT2A | |
| SCHEMBL8428603 | 0.84 | GPR35 (0.37) | GPR35GAAXPO1JUNNFKB1 | |
| Hydrochloric Acid SCHEMBL8336174 | 0.84 | GPR35 (0.35) | GPR35GAAXPO1JUNNFKB1 | |
| Hydrochloric Acid SCHEMBL8336402 | 0.83 | GPR35 (0.35) | GPR35GAAXPO1JUNNFKB1 | |
| Hydrochloric Acid SCHEMBL8340423 | 0.83 | MAPT (0.40) | GPR35P2RX1TMPRSS4MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8331420 | 0.83 | GPR35 (0.36) | GPR35GAAXPO1JUNNFKB1 | |
| SCHEMBL8426429 | 0.82 | JUN (0.39) | GPR35GAAJUNNFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0791577-B1 | Ortho-substituted benzylguanidines, process for their preparation and their use as medicament or diagnostic agent as well as medicament containing them | HOECHST AG (DE) | 1999-11-03 | — | — | EP | claimed |