Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.37 |
| ▸ | CMA1 | P23946 | 9/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 2/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430198 | 0.97 | ELANE (0.38) | ELANECMA1HDAC8MEN1KMT2A | |
| SCHEMBL8430132 | 0.81 | ELANE (0.53) | ELANE | |
| SCHEMBL7329397 | 0.80 | ELANE (0.39) | ELANECMA1MEN1KMT2A | |
| SCHEMBL8510794 | 0.78 | ELANE (0.41) | ELANECMA1MEN1KMT2A | |
| SCHEMBL7339091 | 0.78 | ELANE (0.55) | ELANE | |
| SCHEMBL7330747 | 0.78 | ELANE (0.39) | ELANECMA1MEN1KMT2A | |
| SCHEMBL7966452 | 0.75 | ELANE (0.41) | ELANECMA1MEN1KMT2A | |
| SCHEMBL7962916 | 0.74 | ELANE (0.49) | ELANE | |
| SCHEMBL7364606 | 0.74 | ALDH1A1 (0.37) | ELANECMA1 | |
| SCHEMBL8428427 | 0.73 | CTSK (0.36) | ELANEMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6008196-A | AN ENZYME INHIBITORS OF HUMAN NEUTROPHIL ELASTASE | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-28 | — | — | US | disclosed |
| EP-0763055-B1 | PERFLUOROALKYL KETONE INHIBITORS OF ELASTASE AND PROCESSES FOR MAKING THE SAME | MERRELL PHARMA INC (US) | 1999-11-03 | — | — | EP | disclosed |