Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Cyclopentane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.77 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.77 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | BLM | P54132 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GABRR1 | P24046 | 4/20 | 0.45 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL8642558 | 1.00 | — | — | |
| Cyclohexane SCHEMBL3895013 | 1.00 | GLRA1 (0.77) | GLRA1SLC6A9OR51E2LMNAALDH1A1 | |
| Glycine SCHEMBL10595751 | 1.00 | — | — | |
| Glycine SCHEMBL2116443 | 0.88 | — | — | |
| Glycine SCHEMBL93765 | 0.88 | GLRA1 (1.00) | GLRA1SLC6A9OR51E2LMNAALDH1A1 | |
| Glycine SCHEMBL391786 | 0.88 | GLRA1 (1.00) | GLRA1SLC6A9OR51E2LMNAALDH1A1 | |
| Glycine SCHEMBL3640989 | 0.88 | GLRA1 (1.00) | GLRA1SLC6A9OR51E2LMNAALDH1A1 | |
| Glycine SCHEMBL391027 | 0.88 | GLRA1 (1.00) | GLRA1SLC6A9OR51E2LMNAALDH1A1 | |
| Glycine SCHEMBL6163 | 0.88 | — | — | |
| Glycine SCHEMBL6675874 | 0.88 | GLRA1 (1.00) | GLRA1SLC6A9OR51E2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5872104-A | BACTERICIDES AND RESISTANT BACTERIA WITH METHYLATION INHIBITORS | ORIDIGM CORPORATION (US) | 1999-02-16 | — | — | US | disclosed |
| US-5834431-A | Des-Arg9 -BK antagonists | CORTECH, INC. (US) | 1998-11-10 | — | — | US | disclosed |
| WO-1997009346-A1 | DES-ARG9-BK ANTAGONISTS | CORTECH, INC. (US) | 1997-03-13 | — | — | WO | disclosed |
| WO-1996020010-A1 | COMBINATION FOR REDUCING ANTIMICROBIAL RESISTANCE USING A METHYLATION INHIBITOR IN COMBINATION WITH AN ANTIBIOTIC | ORIDIGM CORPORATION (US) | 1996-07-04 | — | — | WO | disclosed |