Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 3/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SELL | P14151 | 1/20 | 0.35 |
| ▸ | SELP | P16109 | 1/20 | 0.35 |
| ▸ | SELE | P16581 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.35 |
| ▸ | ITGAV | P06756 | 2/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | F7 | P08709 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8432519 | 0.89 | PTGER4 (0.45) | ITGB3ITGA2BPTGER1PTGER4PTGER3 | |
| SCHEMBL8429316 | 0.88 | ITGB3 (0.39) | ITGB3ITGA2BPTGER1PTGER4PTGER3 | |
| SCHEMBL8432900 | 0.87 | PTGER4 (0.40) | ITGB3ITGA2BPTGER1PTGER4PTGER3 | |
| SCHEMBL8432817 | 0.86 | CYP17A1 (0.33) | SELLSELPSELE | |
| SCHEMBL8432812 | 0.85 | ITGB3 (0.39) | ITGB3ITGA2BPTGER1PTGER4PTGER3 | |
| SCHEMBL8432805 | 0.85 | ITGB3 (0.37) | ITGB3ITGA2BPTGER1PTGER4PTGER3 | |
| SCHEMBL8430865 | 0.80 | PTGER4 (0.47) | ITGB3ITGA2BPTGER1PTGER4PTGER3 | |
| SCHEMBL8531192 | 0.79 | PTGER4 (0.48) | ITGB3ITGA2BPTGER1PTGER4PTGER3 | |
| SCHEMBL8530521 | 0.78 | ENPP2 (0.47) | ITGB3ITGA2BPTGER1PTGER4PTGER3 | |
| SCHEMBL8429182 | 0.77 | PTGER4 (0.44) | ITGB3ITGA2BPTGER1PTGER4PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |