Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 5/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 5/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.47 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 7/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8432519 | 0.91 | PTGER4 (0.45) | PTGER4PTGER3PTGER1PTGER2ENPP2 | |
| SCHEMBL8531192 | 0.83 | PTGER4 (0.48) | PTGER4PTGER3PTGER1PTGER2ENPP2 | |
| SCHEMBL8535168 | 0.83 | PTGER4 (0.45) | PTGER4PTGER3PTGER1PTGER2ENPP2 | |
| SCHEMBL8429101 | 0.82 | PTGER4 (0.47) | PTGER4PTGER3PTGER1PTGER2ITGB3 | |
| SCHEMBL8428906 | 0.80 | ITGB3 (0.39) | PTGER4PTGER3PTGER1PTGER2ENPP2 | |
| SCHEMBL8429316 | 0.80 | ITGB3 (0.39) | PTGER4PTGER3PTGER1PTGER2ENPP2 | |
| SCHEMBL8530521 | 0.80 | ENPP2 (0.47) | PTGER4PTGER3PTGER1PTGER2ENPP2 | |
| SCHEMBL8432900 | 0.79 | PTGER4 (0.40) | PTGER4PTGER3PTGER1PTGER2ENPP2 | |
| SCHEMBL8432812 | 0.77 | ITGB3 (0.39) | PTGER4PTGER3PTGER1PTGER2MEN1 | |
| SCHEMBL8432805 | 0.77 | ITGB3 (0.37) | PTGER4PTGER3PTGER1PTGER2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |