Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 6/20 | 0.43 |
| ▸ | CA2 | P00918 | 6/20 | 0.43 |
| ▸ | CA4 | P22748 | 2/20 | 0.43 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8693780 | 0.83 | CA1 (0.39) | CA1CA2CA4PFKFB3MEN1 | |
| SCHEMBL8694027 | 0.82 | CA1 (0.38) | CA1CA2CA4PFKFB3MEN1 | |
| SCHEMBL8429109 | 0.77 | MEN1 (0.37) | CA1CA2CA4MEN1KMT2A | |
| SCHEMBL8697026 | 0.76 | CA1 (0.40) | CA1CA2CA4MEN1KMT2A | |
| SCHEMBL8431264 | 0.75 | CA1 (0.36) | CA1CA2CA4MEN1KMT2A | |
| SCHEMBL6777725 | 0.75 | RAB9A (0.50) | CA1CA2PFKFB3MEN1KMT2A | |
| SCHEMBL8538572 | 0.73 | KMT2A (0.36) | CA1CA2CA4MEN1KMT2A | |
| SCHEMBL8432297 | 0.73 | RAB9A (0.43) | MEN1KMT2AALDH1A1SMN1; SMN2F2 | |
| SCHEMBL8429467 | 0.70 | CYP1A2 (0.41) | CA1CA2CA4PFKFB3MEN1 | |
| SCHEMBL8432262 | 0.70 | ERCC5 (0.38) | CA1CA2CA4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |