Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8432297 | 0.86 | RAB9A (0.43) | MEN1KMT2ANPC1RAB9AGAA | |
| SCHEMBL8432262 | 0.81 | ERCC5 (0.38) | MEN1KMT2ANPC1RAB9AMITF | |
| SCHEMBL8534258 | 0.78 | KMT2A (0.34) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8429166 | 0.77 | CA1 (0.43) | MEN1KMT2ANPC1SMN1; SMN2CA1 | |
| SCHEMBL8431264 | 0.75 | CA1 (0.36) | MEN1KMT2ANPC1RAB9AGAA | |
| SCHEMBL6777725 | 0.75 | RAB9A (0.50) | MEN1KMT2ANPC1RAB9AMITF | |
| SCHEMBL8538572 | 0.73 | KMT2A (0.36) | MEN1KMT2ANPC1RAB9AGAA | |
| SCHEMBL8534298 | 0.72 | KMT2A (0.34) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8693780 | 0.72 | CA1 (0.39) | MEN1KMT2ACA1CA2CA4 | |
| SCHEMBL8429249 | 0.71 | MAPK1 (0.33) | KMT2AMITFPOLBMAPK1FABP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |