Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.32 |
| ▸ | TSPO | P30536 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | MAP2K4 | P45985 | 4/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.31 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 0.31 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.30 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430246 | 0.90 | MAP2 (0.36) | TSPOMAP2K4MAPK1 | |
| SCHEMBL8430237 | 0.86 | ESR1 (0.39) | KMT2AMAP2K4ALOX12MAPK1 | |
| SCHEMBL8430303 | 0.81 | MEN1 (0.40) | KMT2AMAPK1 | |
| SCHEMBL6505678 | 0.69 | NR1H2 (0.41) | KMT2AALOX12 | |
| SCHEMBL7484772 | 0.67 | PTGS2 (0.52) | — | |
| SCHEMBL7484432 | 0.67 | PTGS2 (0.48) | — | |
| SCHEMBL7482816 | 0.66 | KMT2A (0.31) | KMT2A | |
| SCHEMBL7487942 | 0.66 | GPR17 (0.43) | — | |
| SCHEMBL8430715 | 0.64 | IKBKB (0.32) | IKBKBMAP3K14 | |
| SCHEMBL17482010 | 0.64 | CHEK1 (0.38) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965619-A | ADMINISTERING AN INDENE DERIVATIVE OF GIVEN FORMULA, SUCH AS 1-(2,4,6-TRIMETHOXYBENZYLIDENE)-5-DIMETHYLAMINO-2-METHYL-3-INDENYL ACETIC ACID, TO TREAT PRECANCEROUS LESIONS SUCH AS COLONIC ADENOMATOUS POLYPS; SIDE EFFECT REDUCTION | CELL PATHWAYS INC. (US) | 1999-10-12 | — | — | US | disclosed |