Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | PSD | A5PKW4 | 6/20 | 0.35 |
| ▸ | SLC27A2 | O14975 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430246 | 0.85 | MAP2 (0.36) | HPGDALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL8430237 | 0.81 | ESR1 (0.39) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL4836695 | 0.67 | POLB (0.51) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL8430304 | 0.67 | MAPT (0.36) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL4605520 | 0.66 | TSHR (0.50) | MEN1KMT2AMAPTHTTHPGD | |
| SCHEMBL4013435 | 0.66 | MAPT (0.74) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL8428278 | 0.65 | AMY1A (0.42) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL7487942 | 0.65 | GPR17 (0.43) | — | |
| SCHEMBL8428276 | 0.63 | MAPT (0.31) | MAPTHPGDLMNASMN1; SMN2NPSR1 | |
| SCHEMBL29595163 | 0.62 | HSD17B10 (0.52) | MEN1KMT2AMAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965619-A | ADMINISTERING AN INDENE DERIVATIVE OF GIVEN FORMULA, SUCH AS 1-(2,4,6-TRIMETHOXYBENZYLIDENE)-5-DIMETHYLAMINO-2-METHYL-3-INDENYL ACETIC ACID, TO TREAT PRECANCEROUS LESIONS SUCH AS COLONIC ADENOMATOUS POLYPS; SIDE EFFECT REDUCTION | CELL PATHWAYS INC. (US) | 1999-10-12 | — | — | US | disclosed |