Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPPA | P01160 | 2/20 | 0.38 |
| ▸ | MME | P08473 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ACE | P12821 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.30 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.30 |
| ▸ | REN | P00797 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430337 | 0.93 | NPPA (0.40) | NPPAMMEMEN1KMT2ASPHK1 | |
| SCHEMBL5869416 | 0.89 | NPPA (0.40) | NPPAMMEMEN1KMT2ASPHK1 | |
| SCHEMBL8249944 | 0.89 | NPPA (0.40) | NPPAMMEMEN1KMT2ASPHK1 | |
| SCHEMBL8255171 | 0.82 | NPPA (0.42) | NPPAMMEMEN1KMT2ASPHK1 | |
| SCHEMBL5869917 | 0.82 | NPPA (0.42) | NPPAMMEMEN1KMT2ASPHK1 | |
| SCHEMBL8430592 | 0.81 | REN (0.34) | ADAM17ACESMN1; SMN2BCHEPSMB10 | |
| SCHEMBL8430006 | 0.80 | ADRB3 (0.36) | MEN1KMT2AACESMN1; SMN2BCHE | |
| SCHEMBL8437068 | 0.78 | ACE (0.43) | NPPAMMEADAM17ACEPSMB2 | |
| SCHEMBL8430331 | 0.75 | ACE (0.44) | NPPAMMEADAM17ACEPSMB2 | |
| SCHEMBL8436604 | 0.74 | PPARG (0.42) | KMT2AACEALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | ACE, ACE2, AGTR2 | NPPA 521/4885MME 11/4885MEN1 3996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.