Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 2/20 | 0.32 |
| ▸ | PPARA | Q07869 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CAPN1 | P07384 | 3/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430716 | 0.89 | MAPK1 (0.43) | RAB9AALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL5869832 | 0.88 | ACE2 (0.38) | RAB9AALDH1A1L3MBTL1SMN1; SMN2CTSL | |
| SCHEMBL8430015 | 0.87 | ROCK1 (0.39) | MAPK1CAPN1HDAC3HDAC8HDAC6 | |
| SCHEMBL8430332 | 0.82 | SHMT1 (0.38) | RAB9AALDH1A1SMN1; SMN2CTSKKDM4E | |
| SCHEMBL8430327 | 0.80 | MEN1 (0.34) | ACEHDAC6KMT2AMEN1HDAC1 | |
| SCHEMBL8430339 | 0.80 | NPPA (0.38) | ALDH1A1MAPK1ACEFNTAFNTB | |
| SCHEMBL5869790 | 0.77 | ACE2 (0.48) | RAB9AALDH1A1L3MBTL1SMN1; SMN2CTSL | |
| SCHEMBL8249956 | 0.77 | ACE2 (0.48) | RAB9AALDH1A1L3MBTL1SMN1; SMN2CTSL | |
| SCHEMBL8430348 | 0.76 | ACE (0.44) | CTSBCTSKCAPN1ACEHDAC8 | |
| SCHEMBL8430008 | 0.76 | ACE2 (0.42) | ALDH1A1MAPK1ACEHDAC6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | ACE, ACE2, AGTR2 | RAB9A 2897/4885ALDH1A1 1305/4885L3MBTL1 4525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.