Hydrochloric Acid

Hydrochloric Acid

SCHEMBL843038

C=CC(=O)OCC[N+](C)(C)C.C=CN1CCCC1=O.[Cl-]

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM1 known ✓ P11229 5/20 0.36
CHRM3 known ✓ P20309 5/20 0.36
CHRM2 known ✓ P08172 4/20 0.36
ACHE known ✓ P22303 2/20 0.32
CHRM5 P08912 5/20 0.36
MAPT P10636 1/20 0.36
BLM P54132 1/20 0.36
CHRM4 P08173 4/20 0.36
TSHR P16473 6/20 0.35
HPGD P15428 1/20 0.35
ALDH1A1 P00352 3/20 0.34
CHRNB2 P17787 3/20 0.34
CHRNA7 P36544 3/20 0.34
CHRNA4 P43681 3/20 0.34
TP53 P04637 2/20 0.34
HIF1A Q16665 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
HTR1A P08908 2/20 0.34
ADRA2A P08913 1/20 0.34
ADRA1A P35348 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2852122 0.83 TSHR (0.54) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL11674208 0.82 TSHR (0.58) MAPTTSHRHPGDALDH1A1TP53
Acrylic Acid Ethyl Ester SCHEMBL251480 0.81 ALDH1A1 (0.37) MAPTTSHRHPGDALDH1A1TP53
SCHEMBL908782 0.81 TSHR (0.36) CHRM5CHRM1CHRM3CHRM2CHRM4
SCHEMBL2196152 0.80 TSHR (0.51) MAPTTSHRHPGDALDH1A1SMN1; SMN2
SCHEMBL3089075 0.79 CHRM2 (0.37) CHRM5CHRM1CHRM3CHRM2CHRM4
SCHEMBL28770620 0.78 TSHR (0.32) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL8734435 0.78 TSHR (0.55) MAPTTSHRHPGDALDH1A1TP53
Hydrochloric Acid SCHEMBL134541 0.78 CHRM5 (0.57) CHRM5CHRM1CHRM3MAPTBLM
SCHEMBL10579992 0.77 TSHR (0.44) TSHRHPGDALDH1A1TP53HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4805939-B2 2011-11-02 JP claimed
EP-1793916-B1 COMPOSITE MATERIAL COMPRISING LAYERED HYDROPHILIC COATINGS UNIV MCMASTER (CA) 2010-11-24 EP claimed
EP-1793916-A4 COMPOSITE MATERIAL COMPRISING LAYERED HYDROPHILIC COATINGS UNIV MCMASTER (CA) 2008-05-14 EP claimed
EP-1793916-A1 COMPOSITE MATERIAL COMPRISING LAYERED HYDROPHILIC COATINGS McMaster University (CA) 2007-06-13 EP claimed
US-20060121217-A1 Composite material comprising layered hydrophilic coatings MCMASTER UNIVERSITY 2006-06-08 US claimed
WO-2006034575-A1 COMPOSITE MATERIAL COMPRISING LAYERED HYDROPHILIC COATINGS MCMASTER UNIVERSITY (CA) 2006-04-06 WO claimed
US-7883767-B2 two or more consecutive pore-coating layers to a porous support to achieve very hydrophilic composite materials; 1st gel polymer layer having both hydrophobic and hydrophilic properties, second polymer layer which durably coats the surface of the first polymer layer being more hydrophilic than first MCMASTER UNIVERSITY (CA) 2011-02-08 US disclosed
EP-1793916-B1 COMPOSITE MATERIAL COMPRISING LAYERED HYDROPHILIC COATINGS UNIV MCMASTER (CA) 2010-11-24 EP disclosed
EP-1793916-A4 COMPOSITE MATERIAL COMPRISING LAYERED HYDROPHILIC COATINGS UNIV MCMASTER (CA) 2008-05-14 EP disclosed
EP-1793916-A1 COMPOSITE MATERIAL COMPRISING LAYERED HYDROPHILIC COATINGS McMaster University (CA) 2007-06-13 EP disclosed
US-20060121217-A1 Composite material comprising layered hydrophilic coatings MCMASTER UNIVERSITY 2006-06-08 US disclosed
WO-2006034575-A1 COMPOSITE MATERIAL COMPRISING LAYERED HYDROPHILIC COATINGS MCMASTER UNIVERSITY (CA) 2006-04-06 WO disclosed